Hypothesis of Endogenous Anticholinergic Activity in Alzheimer's Disease
نویسندگان
چکیده
منابع مشابه
Magnesium and Alzheimers Disease: The Cholinergic Hypothesis
The cholinergic deficit in Alzheimer’s disease (AD) remains the cornerstone for the understanding of chemical signal transfer. Hypofunctions of cholinergic systems are significantly involved in the signs and symptoms of senile dementia of the Alzheimer type. Cognitive deficits in AD have been widely associated with dysfunction of the cholinergic system. As a diagnostic marker of AD the activity...
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We reported a procedure of serum anticholinergic activity (SAA) measurement and the reliability and reproducibility of the receptor binding assay, and we also described the usefulness of SAA measurement reflecting the anticholinergic activity (AA) in the central nervous system (CNS). According to the results of a 10 times repeated measurement of standard atropine binding, the relative error was...
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Spirochetes, biofilms, and innate immune system activity have all been recently found in the brains of Alzheimer’s disease patients. The mechanism and actions of those factors in producing the disease were discussed in those studies. However, neither the production nor the role of beta amyloid was included in the discussion of those studies. In this commentary, we hypothesize how the developmen...
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ژورنال
عنوان ژورنال: Neurodegenerative Diseases
سال: 2015
ISSN: 1660-2854,1660-2862
DOI: 10.1159/000381511